| 1st Qualifying Round | 2nd Qualifying Round | 3rd Qualifying Round | Play-offs | Group Stage | Round of 16 |
| Quarterfinals | Semifinals | Final |
Rodada:
Jogados
1ª Rodada
15/09/2021 - Quarta
12:45
Sheriff
2
x
0
Shakhtar Donetsk
15:00
Internazionale
0
x
1
Real Madrid
2ª Rodada
28/09/2021 - Terça
12:45
Shakhtar Donetsk
0
x
0
Internazionale
15:00
Real Madrid
1
x
2
Sheriff
3ª Rodada
19/10/2021 - Terça
15:00
Internazionale
3
x
1
Sheriff
15:00
Shakhtar Donetsk
0
x
5
Real Madrid
4ª Rodada
03/11/2021 - Quarta
13:45
Real Madrid
2
x
1
Shakhtar Donetsk
16:00
Sheriff
1
x
3
Internazionale
5ª Rodada
24/11/2021 - Quarta
12:45
Internazionale
2
x
0
Shakhtar Donetsk
15:00
Sheriff
0
x
3
Real Madrid
6ª Rodada
07/12/2021 - Terça
15:00
Real Madrid
2
x
0
Internazionale
15:00
Shakhtar Donetsk
1
x
1
Sheriff