| 1st Qualifying Round | 2nd Qualifying Round | 3rd Qualifying Round | Play-offs | Group Stage | Round of 16 |
| Quarterfinals | Semifinals | Final |
Rodada:
Jogados
1ª Rodada
14/09/2021 - Terça
12:45
Young Boys
2
x
1
Manchester United
15:00
Villarreal
2
x
2
Atalanta
2ª Rodada
29/09/2021 - Quarta
12:45
Atalanta
1
x
0
Young Boys
15:00
Manchester United
2
x
1
Villarreal
3ª Rodada
20/10/2021 - Quarta
15:00
Manchester United
3
x
2
Atalanta
15:00
Young Boys
1
x
4
Villarreal
4ª Rodada
02/11/2021 - Terça
16:00
Atalanta
2
x
2
Manchester United
16:00
Villarreal
2
x
0
Young Boys
5ª Rodada
23/11/2021 - Terça
12:45
Villarreal
0
x
2
Manchester United
15:00
Young Boys
3
x
3
Atalanta
6ª Rodada
08/12/2021 - Quarta
15:00
Manchester United
1
x
1
Young Boys
09/12/2021 - Quinta
13:00
Atalanta
2
x
3
Villarreal